منابع مشابه
Puzzling it out
Scientific research is undergoing significant restructuring. New fields are emerging, once-separate fields are merging, and many of us are trying to figure out how to combine tools and thinking from different areas of science. Nearly a year into my second post-doc, I search for the best metaphor to describe my ongoing metamorphosis from chemist to chemical biologist. In graduate school, I learn...
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Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studi...
متن کاملPuzzling out the genetics of mammalian sex determination.
Mammals possess an XX/XY chromosomal system for sex determination. The presence of SRY, a masterregulatory gene on the Y chromosome, is necessary to induce the undifferentiated, bipotential gonadal primordium (the embryonic genital ridge) to develop as a testis. In the absence of SRY, it develops as an ovary I. Once the gonads differentiate, their maleor female-specific endocrine function is re...
متن کاملPuzzling It Out: Supporting Ontology Evolution with Applications to eGovernment
In recent years, the use of ontologies in information systems has dramatically increased. Ontology design and maintenance, nonetheless, have been and still are daunting tasks. We argue that ontologies need to evolve, or else the semantic infrastructure of the information system will no longer support the organization’s changing needs. Therefore, in this work we aim at tackling the problem of on...
متن کاملPuzzling out Neutrino Mixing through Golden and Silver Measurements
We update a recent work devoted to resolve the degeneracies that appear in the simultaneous extraction of θ13 and δ at future Neutrino Factories (NF, that exploit the golden channels, i.e. νe → νμ (ν̄e → ν̄μ)) and Superbeam experiments (SB, that measure the νμ → νe (ν̄μ → ν̄e) transitions). We consider the neutrino fluxes obtained with a new optics design for the CERNSPL SB and assume the solar par...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2015
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2015.02.008